Neuroprotective potential of cannabidiol:Molecular mechanisms and clinical implications

作     者：Srushti M.Tambe Suraj Mali Purnima D.Amin Mozaniel Oliveira Srushti M.Tambe;Suraj Mali;Purnima D.Amin;Mozaniel Oliveira

作者机构：Department of Pharmaceutical Sciences and TechnologyInstitute of Chemical TechnologyMatunga EastMumbai 400019India Department of Pharmaceutical Sciences and TechnologyBirla Institute of TechnologyRanchi 835215India Adolpho Ducke LaboratoryEmilio Goeldi MuseumPara 66077-830Brazil 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2023年第21卷第3期

页      面：236-244页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico  CNPq  (300983/2022-0) 

主　　题：Cannabis sativa Cannabidiol Natural products Bioactive compounds Anti-neurodegenerative diseases 

摘      要：Cannabidiol(CBD),a nonpsychotropic phytocannabinoid that was once largely disregarded,is currently the subject of significant medicinal study.CBD is found in Cannabis sativa,and has a myriad of neuropharmacological impacts on the central nervous system,including the capacity to reduce neuroinflammation,protein misfolding and oxidative stress.On the other hand,it is well established that CBD generates its biological effects without exerting a large amount of intrinsic activity upon cannabinoid receptors.Because of this,CBD does not produce undesirable psychotropic effects that are typical of marijuana derivatives.Nonetheless,CBD displays the exceptional potential to become a supplementary medicine in various neurological diseases.Curently,many clinical trials are being conducted to investigate this possibility.This review focuses on the therapeutic effects of CBD in managing neurological disorders like Alzheimer s disease,Parkinson s disease and epilepsy.Overall,this review aims to build a stronger understanding of CBD and provide guidance for future fundamental scientific and clinical investigations,opening a new therapeutic window for neuroprotection.