Use of stimulatory responsive soft nanoparticles for intracellular drug delivery
作者机构：Department of Pharmaceutical SciencesWest Virginia University School of PharmacyMorgantownWV 26505USA Department of Clinical PharmacyWest Virginia University School of PharmacyMorgantownWV 26505USA
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第5期
页 面：6974-6990页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：the Cell and Molecular Biology and Biomedical Engineering Training Program(No.5T32GM133369-02)
主 题：nanoparticles biomaterials stimuli-responsive targeted delivery intracellular drug delivery
摘 要：Drug delivery has made tremendous advances in the last *** therapies are increasingly common,with intracellular delivery highly impactful and sought *** drug delivery systems have limitations due to imprecise and non-targeted release *** way this can be addressed is through using stimuli-responsive soft nanoparticles,which contain materials with an organic backbone such as lipids and *** choice of biomaterial is essential for soft nanoparticles to be responsive to internal or external *** nanoparticle must retain its integrity and payload in non-targeted physiological conditions while responding to particular intracellular environments where payload release is *** internal and external factors could stimulate the intracellular release of drugs from *** stimuli include pH,oxidation,enzymes,while external stimuli include ultrasound,light,electricity,magnetic *** responsive soft nanoparticulate systems specifically utilized to modulate intracellular delivery of drugs are explored in this review.
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