A review of patent literature on the regulation of glucose metabolism by six phytocompounds in the management of diabetes mellitus and its complications

作     者：Anusree DasNandy Rajashri Virge Harsha V.Hegde Debprasad Chattopadhyay Anusree DasNandy;Rajashri Virge;Harsha V.Hegde;Debprasad Chattopadhyay

作者机构：ICMR-National Institute of Traditional MedicineBelagavi 590010KarnatakaIndia 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2023年第21卷第3期

页      面：226-235页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Human Resource Development for Health Research 

主　　题：Berberine Curcumin Gingerol Gymnemic acid Gymnemagenin Mangiferin Diabetes mellitus Patents 

摘      要：Diabetes mellitus is a chronic disease,typified by hyperglycemia resulting from failures in complex multifactorial metabolic functions,that requires life-long medication.Prolonged uncontrolled hyperglycemia leads to micro-and macro-vascular complications.Although antidiabetic drugs are prescribed as the first-line treatment,many of them lose efficacy over time or have severe side effects.There is a lack of in-depth study on the patents filed concerning the use of natural compounds to manage diabetes.Thus,this patent analysis provides a comprehensive report on the antidiabetic therapeutic activity of 6 phytocompounds when taken alone or in combinations.Four patent databases were searched,and 17,649 patents filed between 2001 and 2021 were retrieved.0f these,139 patents for antidiabetic therapeutic aids that included berberine,curcumin,gingerol,gymnemic acid,gymnemagenin and mangiferin were analyzed.The results showed that these compounds alone or in combinations,targeting acetylcoenzyme A carboxylase 2,serine/threonine protein kinase,α-amylase,α-glucosidase,lipooxygenase,phosphorylase,peroxisome proliferator-activated receptor-γ(PPAR-γ),protein tyrosine phosphatase 1B,PPARγco-activator-1α,phosphoinositide 3-kinase and protein phosphatase 1 regulatory subunit 3C,could regulate glucose metabolism which are validated by pharmacological rationale.Synergism,or combination therapy,including different phytocompounds and plant extracts,has been studied extensively and found effective,whereas the efficacy of commercial drugs in combination with phytocompounds has not been studied in detail.Curcumin,gymnemic acid and mangiferin were found to be effective against diabetes-related complications.