Nanomaterials disrupting cell-cell junctions towards various diseases
作者机构：School of Chemistry and Pharmaceutical EngineeringMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250000China Institute of Surface Analysis and Chemical BiologyUniversity of JinanJinan 250022China Department of Chemical and Biomolecular EngineeringNational University of SingaporeSingapore 117585Singapore
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第5期
页 面：7053-7074页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：the National Natural Science Foundation of China(Nos.22104073 and 22004048) the Natural Science Foundation of Shandong Province of China(Nos.ZR2021QB119,2022HWYQ-079,and ZR2020QB171) the Youth Innovation Science and Technology Program of Shandong Provincial Universities(No.2021KJ100).
主 题：nanomaterials nanotoxicity cell-cell junctions organ damage
摘 要：As the continuous development of the industrial revolution,nanomaterials with excellent characteristics have been widely applied in various fields,greatly increasing the probability of human exposure to nanomaterials and the concerns about the potential nanotoxicity.Existing studies have shown that the toxicity of nanomaterials may be closely related to oxidative stress,inflammatory response,phagocytosis dysfunction,DNA damage,etc.Based on our focus,nanomaterials may cross the human barrier through various channels and disrupt various cell-cell junctions,while the integrity of cellular barrier is a necessary for the normal physiological function of various organs.However,until now,there is still a lack of systematic discussion in this field.This review illustrates the importance of cell-cell junctions in maintaining various organ functions and highlights the mechanism of various nanomaterials disrupt cell-cell junctions,as well as the possible damage to various organs,such as brain,eye,lung,breast,intestine,placenta,testis,heart,liver,kidney,skin,etc.Awareness of the potential negative effects of nanomaterials will help scientists deeply understand the limitations of nanotechnology,inspiring them to develop safer and more efficient nanomaterials for future personalized nanomedicine.
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