The humoral and cellular immune evasion of SARS-CoV-2 Omicron and sub-lineages

作     者：Tiandan Xiang Junzhong Wang Xin Zheng Tiandan Xiang;Junzhong Wang;Xin Zheng

作者机构：Department of Infectious DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Joint International Laboratory of Infection and ImmunityHuazhong University of Science and TechnologyWuhan 430022China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第6期

页      面：786-795页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the National Science and Technology Major Project of China(92169121) the Applied Basic and Frontier Technology Research Project of Wuhan(2020020601012233) the Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory(JXBS001) 

主　　题：SARS-CoV-2 Omicron Vaccine Antibody evasion Cellular immunity 

摘      要：The recently discovered SARS-CoV-2 variant Omicron(B.1.1.529) has rapidly become a global public health issue.The substantial mutations in the spike protein in this new variant have raised concerns about its ability to escape from pre-existing immunity established by natural infection or vaccination. In this review, we give a summary of current knowledge concerning the antibody evasion properties of Omicron and its subvariants(BA.2, BA.2.12.1,BA.4/5, and BA.2.75) from therapeutic monoclonal antibodies and the sera of SARS-CoV-2 vaccine recipients or convalescent patients. We also summarize whether vaccine-induced cellular immunity(memory B cell and T cell response) can recognize Omicron specifically. In brief, the Omicron variants demonstrated remarkable antibody evasion, with even more striking antibody escape seen in the Omicron BA.4 and BA.5 sub-lineages. Luckily, the third booster vaccine dose significantly increased the neutralizing antibodies titers, and the vaccine-induced cellular response remains conserved and provides second-line defense against the Omicron.