Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension
作者机构：Department of PharmacologyXiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410078China Hunan Provincial Key Laboratory of Cardiovascular ResearchChangsha 410078China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第5期
页 面：7007-7029页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070205[理学-凝聚态物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0901[农学-作物学] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学]
基 金：the National Natural Science Foundation of China(Nos.82173817,81872872,and 21974134) the Hunan Science Fund for Distinguished Young Scholar(No.2021JJ10067,China) Innovation-Driven Project of Central South University(No.202045005,China) Central South University Research Programme of Advanced Interdisciplinary Studies(No.2023QYJC017).
主 题：pulmonary hypertension nanomedicines enhanced penetration and retention effects polymer liposome
摘 要：Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the patients.The latest epidemiological study demonstrates that PH has a much higher incidence than previously thought.PH is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side effects.The PH pathological features offer great opportunities for nanomedicines for PH.Recently,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side effects.However,this promising field of cross-cutting research is far from being widely explored due to the huge professional barriers.To solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of PH.Firstly,we systematical summarized the PH pathological features and the current clinical drug treatment of PH.The advantages of nanomedicines are also deeply discussed in the treatment of PH.Subsequently,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of PH.Finally,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future.
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