Effect of hydroalcoholic leaf extract of Cassia fistula *** typeⅡcollagen-induced arthritis in rats
作者机构：Department of PharmacologyGovt.College of PharmacyRohruShimlaHimachal Pradesh 171207India Department of PharmaceuticsGovt.College of PharmacyRohruShimlaHimachal Pradesh 171207India School of Pharmaceutical SciencesShoolini UniversitySolan Himachal Pradesh 173229India Institute of Pharmaceutical SciencesKurukshetra UniversityKurukshetraHaryana 136119India
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2023年第13卷第5期
页 面：195-204页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the Institute of Pharmaceutical Sciences Kurukshetra University Kurukshetra Haryana India and Govt.College of Pharmacy Rohru District Shimla Himachal Pradesh India
主 题：Cassia fistula Rheumatoid arthritis CollagenⅡ Inflammatory cytokines Docking
摘 要：Objective:To explore the effect of Cassia fistula on collagenⅡ-induced arthritis in ***:The effect of 250 and 500 mg/kg chloroform and hydroalcoholic extract of Cassia fistula leaf on collagenⅡ-induced arthritis was investigated by evaluating paw volume,arthritis index,spleen index,and biochemical *** analysis and docking study were also ***:A dose-dependent reduction in paw volume,arthritic index,and spleen index was observed following oral administration of the chloroform and hydroalcoholic *** with Cassia fistula extracts reduced tumor necrosis factor-α,interleukin(IL)-1β,IL-6,prostaglandin E_(2),aspartate aminotransferase,alanine aminotransferase,total leucocyte count,and erythrocyte sedimentation rate while increasing IL-10 *** addition,Cassia fistula extracts improved joint architecture,and prevented cartilage and bone *** analysis demonstrated that the physcion,1-octacosanol,5,3’,4’-trihydroxy-6-methoxy-7-O-α-Lrhamnopyranosyl-(1,2)-O-β-D-galactopyranoside and scopoletin may be responsible for the anti-arthritic effect of Cassia ***:Cassia fistula suppresses the progression of collagenⅡ-induced arthritis by lowering the inflammatory factors,decreasing paw volume and arthritic index,and alleviating joint ***,further studies are required to confirm the bioactive molecule responsible for the anti-arthritic potential of Cassia fistula.
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