Inorganic virus-like nanoparticles for biomedical applications:a minireview

作     者：Liying Zhao Jiahong Zhou Dawei Deng 

作者机构：Department of Pharmaceutical EngineeringSchool of EngineeringChina Pharmaceutical UniversityNanjing 211198China Department of Biomedical EngineeringSchool of EngineeringChina Pharmaceutical UniversityNanjing 211198China 

出 版 物：《Journal of Future Foods》 (未来食品学报（英文）)

年 卷 期：2024年第4卷第1期

页      面：71-82页

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(82172085) the“Double First-Class”University project(CPU2022QZ14) the Jiangsu Provincial Natural Science Fund for Distinguished Young Scholars(BK20190028) 

主　　题：Nanotopography Virus-like Spike Inorganic particles Biomedical applications 

摘      要：Nature has the ingenious capability to design spiky topological features at the macro-and nanoscales,which exhibits fascinating interface adhesive properties by means of multivalent *** a biomimetic approach,such as nanoscale virus particles are highly infectious toward host cells,a range of organic and inorganic spiky particles(virus-like nanostructures)have been precisely engineered for diverse biomedical ***,organic virus-like particles(VLPs)derived from viral capsids(often termed as virosomes)have been extensively studied and reviewed,but concomitant concerns regarding immunogenicity and risks of mutagenesis limit clinical potential of organic *** contrast,inorganic VLPs(viral-mimicking topography)possess fascinating physicochemical characteristics,such as excellent electrical,optical,magnetic,mechanical and catalytic properties,which make them particularly suitable for biomedical ***,there is no comprehensive review related to inorganic VLPs engineered with non-viral shell for biomedical ***,in this review,we present a brief overview on inorganic VLPs,followed by summarizing the construction and properties of virus-like nanostructures,as well as the mechanisms of nano-bio interface interactions initiated by spiky ***,we focus on the recent advances of VLPs for biomedical applications(including biosensing,antibacterial therapy and cancer treatment).Finally,the future outlook and emerging challenges will be *** review aims to provide future scope of the rational design of inorganic non-viral vectors,especially with respect to gene-based therapy platforms.