Genomic Analysis and Antimicrobial Resistance of Campylobacter jejuni Isolated from Diarrheal Patients—Beijing Municipality,China,2019–2021

作     者：Daitao Zhang Xin Zhang Bing Lyu Yi Tian Ying Huang Changying Lin Hanqiu Yan Lei Jia Mei Qu Quanyi Wang 

作者机构：Beijing Center for Disease Prevention and ControlBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food PoisoningBeijingChina School of Public HealthCapital Medical UniversityBeijingChina 

出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)

年 卷 期：2023年第5卷第19期

页      面：424-433,I0003,I0004页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：complex method complexes 

摘      要：Introduction:Campylobacter jejuni(***)is the leading cause of human bacterial gastroenteritis worldwide and has a major impact on global public *** objective of the present study was to conduct whole genome sequencing(WGS)to determine the genetic diversity,virulence factors,and determinants of antimicrobial resistance of *** during a 3-year surveillance period in Beijing,***:A total of 184 clinical isolates were obtained from sentinel hospital surveillance between 2019 and *** susceptibility testing was conducted using the agar dilution *** was employed to characterize the 184 *** ***:Multilocus sequence typing analysis revealed high genetic diversity among the 184 *** strains,identifying 71 sequence types(STs)and 19 clonal complexes(CCs).The most prevalent ST was ST760(6.5%),and the most common CC was CC21(24.5%),consisting of 11 *** resistance rates were observed for ciprofloxacin(76.6%),nalidixic acid(76.1%),and tetracycline(71.2%).A total of 77 *** isolates(41.8%)exhibited multidrug resistance with 43 resistance *** analysis disclosed the differential distribution of virulence factors related to adherence,colonization,chemotaxis,as well as lipooligosaccharide and capsular polysaccharide *** analysis demonstrated widespread resistance to quinolones and tetracycline,but low rates of macrolides *** phylogeny,based on whole genome single nucleotide polymorphisms,indicated a high degree of clonality and grouped the *** strains into six *** related isolates that were part of a genetic cluster mostly shared a homogenous clonal ***:The present study emphasizes the rising resistance to quinolones and tetracycline,as well as the virulence potential and diverse genotypes identified among *** strains isolated from diarrheal patients in Beijing.