In vivo antioxidant activity of rabbiteye blueberry(Vaccinium ashei cv.'Brightwell')anthocyanin extracts

作     者：Jing WANG Xingyu ZHAO Jiawei ZHENG Daniela D.HERRERA-BALANDRANO Xiaoxiao ZHANG Wuyang HUANG Zhongquan SUI Jing WANG;Xingyu ZHAO;Jiawei ZHENG;Daniela D.HERRERA-BALANDRANO;Xiaoxiao ZHANG;Wuyang HUANG;Zhongquan SUI

作者机构：College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Institute of Agro-Product ProcessingJiangsu Academy of Agricultural SciencesNanjing 210014China School of Food and Biological EngineeringJiangsu UniversityZhenjiang 212013China School of Life SciencesNantong UniversityNantong 226007China Department of Food Science&EngineeringSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第7期

页      面：602-616页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：supported by the Jiangsu Provincial Key Research and Development Program(No.BE2021705) China 

主　　题：Blueberry anthocyanin In vivo antioxidant activity Superoxide dismutase(SOD) Glutathione-peroxidase(GSH-PX/GPX) Malondialdehyde(MDA) 

摘      要：Blueberries are rich in phenolic compounds including anthocyanins which are closely related to biological health *** purpose of this study was to investigate the antioxidant activity of blueberry anthocyanins extracted from Brightwell rabbiteye blueberries in *** one week of adaptation,C57BL/6J healthy male mice were divided into different groups that were administered with 100,400,or 800 mg/kg blueberry anthocyanin extract(BAE),and sacrificed at different time points(0.1,0.5,1,2,4,8,or 12 h).The plasma,eyeball,intestine,liver,and adipose tissues were collected to compare their antioxidant activity,including total antioxidant capacity(T-AOC),superoxide dismutase(SOD)activity and glutathione-peroxidase(GSH-PX/GPX)content,and the oxidative stress marker malondialdehyde(MDA)*** results showed that blueberry anthocyanins had positive concentration-dependent antioxidant activity in *** greater the concentration of BAE,the higher the T-AOC value,but the lower the MDA *** enzyme activity of SOD,the content of GSH-PX,and messenger RNA(mRNA)levels of Cu,Zn-SOD,Mn-SOD,and GPX all confirmed that BAE played an antioxidant role after digestion in mice by improving their antioxidant *** in vivo antioxidant activity of BAE indicated that blueberry anthocyanins could be developed into functional foods or nutraceuticals with the aim of preventing or treating oxidative stress-related diseases.