The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor β in a Mouse Model of Radiculopathy

作     者：Debora Denardin Luckemeyer Wenrui Xie Arthur Silveira Prudente Katherine A.Qualls Raquel Tonello Judith A.Strong Temugin Berta Jun-Ming Zhang 

作者机构：Pain Research CenterDepartment of AnesthesiologyUniversity of Cincinnati College of MedicineCincinnatiOH45267USA Department of Molecular PathobiologyDepartment of Neuroscience and PhysiologyNeuroscience InstituteNew York UniversityNew YorkNY10010USA 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第9期

页      面：1363-1374页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：This work was supported by NIH Grants NS045594 and NS113243 

主　　题：TGF-β Sympathetic Radiculopathy:Inflammation Cytokine 

摘      要：Although sympathetic blockade is clinically used to treat pain,the underlying mechanisms remain *** developed a localized microsympathectomy(mSYMPX),by cutting the grey rami entering the spinal nerves near the rodent lumbar dorsal root ganglia(DRG).In a chemotherapy-induced peripheral neuropathy model,mSYMPX attenuated pain behaviors via DRG macrophages and the anti-inflammatory actions of transforming growth factor-β(TGF-β)and its receptor TGF-β***,we examined the role of TGF-βin sympathetic-mediated radiculopathy produced by local inflammation of the DRG(LID).Mice showed mechanical hypersensitivity and transcriptional and protein upregulation of TGF-β1 and TGF-βR1 three days after *** prevented mechanical hypersensitivity and further upregulated Tgfb1 and *** delivery of TGF-β1 rapidly relieved the LID-induced mechanical hypersensitivity,and TGF-βR1 antagonists rapidly unmasked the mechanical hypersensitivity after LID+*** situ hybridization showed that Tgfb1 was largely expressed in DRG macrophages,and Tgfbr1 in *** suggest that TGF-βsignaling is a general underlying mechanism of local sympathetic blockade.