Recent advances of bioresponsive polymeric nanomedicine for cancer therapy
作者机构：International institutes of MedicineThe Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang ProvinceCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Thoracic SurgeryThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Liangzhu LaboratoryZhejiang University Medical CenterHangzhou 311121China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of General SurgerySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Jinhua Institute of Zhejiang UniversityJinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第2期
页 面：2660-2671页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学]
基 金：the National Key R&D Program of China(No.2021YFA0909900) the National Natural Science Foundation of China(No.52173142) Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents,and the grants from the Startup Package of Zhejiang University.
主 题：drug delivery polymer bioresponsive immunotherapy cancer therapy
摘 要：A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented.
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