Optical Trapping of a Single Molecule of Length Sub-1 nm in Solution
作者机构：Department of PhysicsPen-Tung Sah Institute of Micro-Nano Science and TechnologyState Key Laboratory of Physical Chemistry of Solid SurfacesIKKEMXiamen UniversityXiamen 361005
出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)
年 卷 期：2023年第5卷第4期
页 面：830-840页
核心收录：
学科分类：07[理学] 0703[理学-化学] 0701[理学-数学]
基 金：supported by the National Natural Science Foundation of China(grant nos.T2222002,21973079,22032004,92161118,12174324,21991130,and 21905238) the Ministry of Science and Technology of the People’s Republic of China(grant no.2021YFA1201502) the Natural Science Foundation of Fujian Province(grant no.2021J06008).
主 题：plasmon-enhanced trapping molecular junction mechanically controllable break junction finite-element simulation method single-molecule conductance measurement
摘 要：Plasmonic optical manipulation has emerged as an affordable alternative to manipulate single chemical and biological molecules in nanoscience.Although the theoretical models of sub-5 nm single-molecule trapping have been considered promising,the experimental strategies remain a challenge due to the Brownian motions and weak optical gradient forces with significantly reduced molecular polarizability.Herein,we address direct trapping and in situ sensing of single molecules with unprecedented size,down to∼5Åin solution,by employing an adjustable plasmonic optical nanogap and single-molecule conductance measurement.The theoretical simulations demonstrate that local fields with a high enhancement factor,over 103,were generated at such small nanogaps,resulting in optical forces as large as several piconewtons to suppress the Brownian motion and trap a molecule of length sub-1 nm.This work demonstrates a strategy for directly manipulating the small molecule units,promising a vast multitude of applications in chemical,biological,and materials sciences at the single-molecule level.
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