FeS@LAB-35@Ti_(3)C_(2)as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing
作者机构：National and Local Joint Engineering Research Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Medical SchoolNanjing UniversityNanjing 210093China Jiangsu Engineering Research Center of Interfacial ChemistryNanjing UniversityNanjing 210023China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第2期
页 面：2840-2850页
核心收录：
学科分类：07[理学] 070304[理学-物理化学(含∶化学物理)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：supported by the Jiangsu Province Science and Technology Support Plan(No.BE2019391) the Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.
主 题：MXene FeS nanozyme photothermal enhanced chemodynamic antibacterial activity wound healing
摘 要：The abuse of antibiotics leads to a significant increase in bacterial resistance,which makes it difficult to treat bacterial infections.Therefore,it is urgent to develop new strategies for efficient antibacterial and wound healing.Recently,nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency.In this study,we report a FeS@lauramidopropyl betaine(LAB-35)@Ti_(3)C_(2)nanozyme as a high-efficiency antibacterial agent for near infrared(NIR)light induced photothermal enhanced chemodynamic antibacteria and wound healing.The FeS@LAB-35@Ti_(3)C_(2)nanozyme possesses peroxidase-like catalysis activity,which can promote the generation of hydroxyl radicals(·OH)through catalyzing the decomposition of H_(2)O_(2).FeS@LAB-35@Ti_(3)C_(2)has photothermal conversion efficiency(η=65.1%),and it exhibits enhanced catalytic activity under NIR light irradiation.The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti_(3)C_(2)against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.The animal experiments indicate that FeS@LAB-35@Ti_(3)C_(2)nanozyme can effectively inhibit wound ulceration and promote wound healing.Overall,this study proposes FeS@LAB-35@Ti_(3)C_(2)nanozyme that integrates chemodynamic and photothermal therapy,which provides an efficient strategy for bacterial inhibition and wound healing.
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