Sex-specific and dose-response relationships of urinary cobalt and molybdenum levels with glucose levels and insulin resistance in U.S. adults

作     者：Jingli Yang Yongbin Lu Yana Bai Zhiyuan Cheng Jingli Yang;Yongbin Lu;.Yana Bai;Zhiyuan Cheng

作者机构：College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Department of Epidemiology and StatisticsSchool of Public HealthLanzhou UniversityLanzhou 730000China School of Public Health and Emergency ManagementSouthern University of Science and TechnologyShenzhen 518055China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第124卷第2期

页      面：42-49页

核心收录：

学科分类：100405[医学-卫生毒理学] 0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 0701[理学-数学] 10[医学] 

基　　金：supported by the National Institutes of Health (U.S.)-(NIH Grant Number: 1R01ES029082) 

主　　题：Bayesian kernel machine regression Cobalt Diabetes Insulin resistance Molybdenum 

摘      要：Growing studies have linked metal exposure to diabetes risk.However,these studies had inconsistent results.We used a multiple linear regression model to investigate the sexspecific and dose-response associations between urinary metals(cobalt(Co)and molybdenum(Mo))and diabetes-related indicators(fasting plasma glucose(FPG),hemoglobin A1c(HbA1c),homeostasis model assessment for insulin resistance(HOMA-IR),and insulin)in a cross-sectional study based on the United States National Health and Nutrition Examination Survey.The urinary metal concentrations of 1423 eligible individuals were stratified on the basis of the quartile distribution.Our results showed that the urinary Co level in males at the fourth quartile(Q4)was strongly correlated with increased FPG(β=0.61,95%CI:0.17–1.04),HbA1c(β=0.31,95%CI:0.09–0.54),insulin(β=8.18,95%CI:2.84–13.52),and HOMA–IR(β=3.42,95%CI:1.40–5.44)when compared with first quartile(Q1).High urinary Mo levels(Q4 vs.Q1)were associated with elevated FPG(β=0.46,95%CI:0.17–0.75)and HbA1c(β=0.27,95%CI:0.11–0.42)in the overall population.Positive linear dose-response associations were observed between urinary Co and insulin(Pnonlinear=0.513)and HOMA–IR(Pnonlinear=0.736)in males,as well as a positive linear dose-response relationship between urinary Mo and FPG(Pnonlinear=0.826)and HbA1c(Pnonlinear=0.376)in the overall population.Significant sex-specific and dose-response relationships were observed between urinary metals(Co and Mo)and diabetes-related indicators,and the potential mechanisms should be further investigated.