House dust mite allergens and nitrated products: Identification and risk assessment in indoor dust

作     者：Fan Xu Jingyi Tian Fangxing Yang Fan Xu;Jingyi Tian;Fangxing Yang

作者机构：Key Laboratory of Environment Remediation and Ecological HealthMinistry of EducationCollege of Natural Resources and Environmental ScienceZhejiang UniversityHangzhou 310058China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2023年第124卷第2期

页      面：198-204页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070602[理学-大气物理学与大气环境] 0837[工学-安全科学与工程] 0706[理学-大气科学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0813[工学-建筑学] 0833[工学-城乡规划学] 0713[理学-生态学] 

基　　金：financially supported by the National Natural Science Foundation of China (No. 41977341) Natural Science Foundation of Zhejiang Province, China (No. LGF21B070007) Research Center for Air Pollution and Health, Zhejiang University (No. I21405-11) 

主　　题：Allergen Air pollution Health risk House dust mite(HDM) Nitration 

摘      要：Air pollutants can potentially lead to nitration of allergic proteins,thus promoting sensitization of these allergens.However,little is currently known about the nitration status of house dust mite(HDM)allergens.We identified the occurrence of nitrated products of two major HDM allergens Der f 1 and Der p 1 in dust samples collected from college dormitories in eastern China and assessed their associated health risk.The results showed that both non-nitrated and nitrated forms of the two allergens were detected in the dust in the range of non-detected(ND)-10.6,1.44-15.4,ND-22.4,ND-7.28μg/g for non-nitrated Der f 1,nitrated Der f 1,non-nitrated Der p 1 and nitrated Der p 1,respectively.The median rates of nitration were determined as 74.0%for Der f 1 and 20.4% for Der p 1 at consideration of one nitration site.Further analysis reveals that the levels of HDM allergens and their nitrated products were found to be generally higher during winter,in dormitories of lower altitude and with female occupants.Furthermore,the calculated risk indexes were at considerably high levels.Our findings suggest that nitrated HDM allergens have already accumulated in the environment at such significant levels and their associated health risk calls for our immediate attention.