Aggregation-induced emission luminogens for in vivo molecular imaging and theranostics in cancer
作者机构：Department of Nuclear Medicine and PET CenterThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Institute of Nuclear Medicine and Molecular Imaging of Zhejiang UniversityHangzhouZhejiangChina Key Laboratory of Medical Molecular Imaging of Zhejiang ProvinceHangzhouZhejiangChina Department of Chemistry and the Tsinghua Center for Frontier Polymer ResearchTsinghua UniversityBeijingChina College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhouZhejiangChina Key Laboratory for Biomedical Engineering of Ministry of EducationZhejiang UniversityHangzhouZhejiangChina Human Phenome InstituteFudan UniversityShanghaiChina
出 版 物：《Aggregate》 (聚集体(英文))
年 卷 期：2023年第4卷第5期
页 面：34-62页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,Grant/Award Numbers:21788102,32027802 Key R&D Program of Zhejiang,Grant/Award Number:2022C03071 Fundamental Research Funds for the Central Universities
主 题：aggregation-induced emission cancer near-infrared imaging phototherapy targeting strategy theranostics
摘 要：Cancer is one of the most fatal diseases for ***-induced emission luminogens(AIEgens)have been recently used as molecular imaging or therapeutic agents in cancers,due to the advantages of large Stokes shift,high quantum yield,great biocompatibility,and strong *** can specifically target different types of cancer via diverse targeting ***-based fluorescence imaging,especially near-infrared imaging,demonstrated deep penetration and suitable signal-to-noise ratio,which allows reliable in vivo cancer *** with other imaging modalities,AIEgen-based multimodal imaging could provide multidimensional cancer hallmarks from different *** addition,AIEgenbased phototherapy can be used for photodynamic therapy and photothermal therapy,which facilitate ablation of cancer cells with good biosafety and high therapeutic effects in *** nanoparticles fabricated with some specific chemicals,drugs,or siRNA,could display synergistic therapeutic effects for *** paper comprehensively describes the current status and future perspectives of AIEgens,which have showed a great potential for the future preclinical and clinical translation on in vivo molecular imaging and theranostics in cancer.
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