A hidden translatome in tumors——the coding lncRNAs

作     者：Jinsong Wang Wenna Wang Fei Ma Haili Qian Jinsong Wang;Wenna Wang;Fei Ma;Haili Qian

作者机构：State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第12期

页      面：2755-2772页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2021YFF1201300,2022YFE0103600) the National Natural Science Foundation of China (82073094) the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-014) the Open Issue of State Key Laboratory of Molecular Oncology (SKL-KF-2021-16) the Independent Issue of State Key Laboratory of Molecular Oncology (SKL-2021-16) 

主　　题：lncRNA translatome peptide tumor 

摘      要：Long noncoding RNAs(lncRNAs)have been extensively identified in eukaryotic genomes and have been shown to play critical roles in the development of multiple *** the application and development of ribosome analysis and sequencing technologies,advanced studies have discovered the translation of *** lncRNAs were originally defined as noncoding RNAs,many lncRNAs actually contain small open reading frames that are translated into *** opens a broad area for the functional investigation of ***,we introduce prospective methods and databases for screening lncRNAs with functional *** also summarize the specific lncRNA-encoded proteins and their molecular mechanisms that promote or inhibit ***,the role of lncRNA-encoded peptides/proteins holds promise in cancer research,but some potential challenges remain *** review includes reports on lncRNA-encoded peptides or proteins in cancer,aiming to provide theoretical basis and related references to facilitate the discovery of more functional peptides encoded by lncRNA,and to further develop new anti-cancer therapeutic targets as well as clinical biomarkers of diagnosis and prognosis.