Iron accumulation and its impact on osteoporotic fractures in postmenopausal women

作     者：Hui CAI Huimei ZHANG Weiting HE Heng ZHANG Hui CAI;Huimei ZHANG;Weiting HE;Heng ZHANG

作者机构：Department of Pharmacythe First Affiliated Hospital of Bengbu Medical CollegeBengbu Medical CollegeBengbu 233004China School of PharmacyBengbu Medical CollegeBengbu 233030China School of Clinical MedicineBengbu Medical CollegeBengbu 233030China Department of Orthopedicsthe First Affiliated Hospital of Bengbu Medical CollegeLaboratory of Tissue and Transplant in Anhui ProvinceBengbu Medical CollegeBengbu 233004China Department of OrthopedicsJinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第4期

页      面：301-311页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0836[工学-生物工程] 10[医学] 

基　　金：Outstanding Youth Science Fund Project of the First Affiliated Hospital of Bengbu Medical College(No.2021byyfyyq04) China. 

主　　题：Iron accumulation Postmenopausal osteoporosis Bone metabolism Osteoporotic fracture 

摘      要：Postmenopausal osteoporosis is a kind of degenerative disease,also described as“invisible killer.Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their lives.Iron accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000μg/L.It has been found that iron accumulation and osteoporosis could occur simultaneously with the decrease in estrogen level after menopause.In recent years,many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis,and a significant correlation has been found between iron accumulation and fragility fractures.In this review,we summarize and analyze the relevant literature including randomized controlled trials,systematic reviews,and meta-analyses between January 1996 and July 2022.We investigate the mechanism of the effect of iron accumulation on bone metabolism and discuss the relationship of iron accumulation,osteoporosis,and postmenopausal fragility fractures,as well as the main clinical treatment strategies.We conclude that it is necessary to pay attention to the phenomenon of iron accumulation in postmenopausal women with osteoporosis and explore the in-depth mechanism of abnormal bone metabolism caused by iron accumulation,in order to facilitate the discovery of effective therapeutic targets for postmenopausal osteoporosis.