Vaginal Delivery and Breastfeeding Benefit Infant Immune Response to Hepatitis B Vaccine:A Prospective Cohort Study

作     者：Huiqing Liu Lili Li Yali Li Minmin Liu Yarong Song Feng Ding Xiaoshu Zhang Jie Li 

作者机构：Jinchang Municipal Center for Disease Control and PreventionJinchangGansuChina Department of Microbiology&Infectious Disease CenterSchool of Basic Medical SciencesPeking University Health Science CenterBeijingChina Gansu Provincial Center for Disease Control and PreventionLanzhouGansuChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2023年第11卷第4期

页      面：899-907页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was supported by grants from the Chinese Foundation for Hepatitis Prevention and Control(YGFK20180006) 

主　　题：Hepatitis B vaccine Immune response Anti-HBs Vaginal delivery Breastfeeding 

摘      要：Background and Aims:Natural vaginal delivery and breastfeeding favor the development of a strong immune system in infants,and the immune response of infants to vaccines is closely related to their immune *** large prospective cohort study aimed to explore the effects of delivery and feeding mode on infant’s immune response to hepatitis B vaccine(HepB).Methods:A total of 1,254 infants who completed the whole course of HepB immunization and whose parents were both HBsAg negative were enrolled from infants born in Jinchang City during 2018-2019 by cluster sampling ***:Twenty(1.59%)of the 1,254 infants were nonresponders to *** the other 1,234 infants,10.05%(124/1,234),81.69%(1,008/1,234)and 8.27%(102/1,234)of infants had low,medium,and high responses to HepB,*** regression analysis showed that cesarean section(OR:8.58,95%CI:3.11-23.65,p0.001)and birth weight3.18 kg(OR:5.58,95%CI:1.89-16.51,p=0.002)were independent risk factors for infant nonresponse to HepB,and cesarean section(OR:7.63,95%CI:4.64-12.56,p0.001),formula feeding(OR:4.91,95%CI:1.47-16.45,p=0.001),maternal antiHBs negativity(OR:27.2,95%CI:10.67-69.35,p0.001),paternal non-response history of HepB(OR:7.86,95%CI:2.22-27.82,p=0.014)and birth weight3.22 kg(OR:4.00,95%CI:2.43-6.59,p0.001)were independent risk factors for infant low response to *** cases where birth weight and genetic factors are unmodifiable and maternal anti-HBs effects are controversial,it makes sense to enhance infant response by changing delivery and feeding ***:Natural vaginal delivery and breastfeeding are beneficial to the infant’s immune response to HepB.