Effects of bisphenol A and bisphenol analogs on the nervous system

作     者：Chunxia Li Chen Sang Shuo Zhang Sai Zhang Hui Gao 

作者机构：Department of Obstetrics and GynecologyBeijing Tian Tan HospitalCapital Medical UniversityBeijing 100730China School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第3期

页      面：295-304页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：supported by a grant from the National Natural Science Foundation of China(No.21577095). 

主　　题：Bisphenol A Bisphenol analogs Nervous system Learning/memory disorders Neurodegenerative diseases Gender Mechanisms 

摘      要：Estrogen impacts neural development;meanwhile, it has a protective effect on the brain. Bisphenols, primarily bisphenol A (BPA), can exert estrogen-like or estrogen-interfering effects by binding with estrogen receptors. Extensive studies have suggested that neurobehavioral problems, such as anxiety and depression, can be caused by exposure to BPA during neural development. Increasing attention has been paid to the effects on learning and memory of BPA exposure at different developmental stages and in adulthood. Further research is required to elucidate whether BPA increases the risk of neurodegenerative diseases and the underlying mechanisms, as well as to assess whether BPA analogs, such as bisphenol S and bisphenol F, influence the nervous system.