Radiation-induced tumor immune microenvironments and potential targets for combination therapy

作     者：Siyu Guo Yihan Yao Yang Tang Zengfeng Xin Dang Wu Chao Ni Jian Huang Qichun Wei Ting Zhang Siyu Guo;Yihan Yao;Yang Tang;Zengfeng Xin;Dang Wu;Chao Ni;Jian Huang;Qichun Wei;Ting Zhang

作者机构：Department of Radiation OncologySecond Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang ProvinceSecond Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina Cancer Institute(Key Laboratory of Cancer Prevention and InterventionNational Ministry of Education)Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina Cancer CenterZhejiang UniversityHangzhouChina Department of Orthopedic SurgerySecond Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina Department of Breast SurgerySecond Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第6期

页      面：2773-2794页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grant from the National Natural Science Foundation of China(82173089,T.Z.,82073332,Q.W,81930079,J.H.,U22A2031,J.H,82073142,D.W.,82073151,C.N.,82273275,C.N.) National Key Research and Development Program(2022YFA1105200,J.H.) Natural Science Foundation of Zhejiang Province(LY21H100004,T.Z:,LY19H160050,D.W.,LR19H160001,C.N.,LGF22H060010,Z.X.) Zhejiang Research and Development Project(2022C03019,J.H.) Medical Science and Technology Project of Zhejiang Province(2021KY697,Z.X.,2021RC063,T.Z.) Beijing CSCO Clinical Oncology Research Foundation(Y-2020Sciclone/ms-0099,T.Z.,Y-2019Sciclone-019,T.Z.) 

主　　题：microenvironment alterations surgery 

摘      要：As one of the four major means of cancer treatment including surgery,radiotherapy(RT),chemotherapy,immunotherapy,RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after *** RT is an important modality for cancer treatment,the consequential changes caused by RT in the tumor microenvironment(TME)have not yet been fully ***-induced damage to cancer cells leads to different outcomes,such as survival,senescence,or *** RT,alterations in signaling pathways result in changes in the local immune ***,some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions,leading to the development of *** who are radioresistant respond poorly to RT and may experience cancer *** that the emergence of radioresistance is inevitable,new radiosensitization treatments are urgently *** this review,we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of ***,this review highlights the possibilities of synergistic therapy by building on existing research.