Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers
作者机构：Department of Chemistryand Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第4期
页 面：5169-5175页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 070303[理学-有机化学] 0703[理学-化学] 1009[医学-特种医学]
基 金：supported by the National Natural Science Foundation of China(Nos.21877049,22177038,and 32171296) Guangdong Natural Science Foundation(Nos.2022A1515012235 and 2020B1515120043) Guangdong Pearl River Talent Program(No.2017GC010354) Innovation Team Project in Guangdong Colleges and Universities(Nos.2019KCXTD008 and 2019KTSCX012).
主 题：selenium lanthanide coordination nanoframeworks radiotherapy radiosensitizers
摘 要：Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side effects.Developing low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side effects.Here,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to X-ray.The onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom engineering.This study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.
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