Recent trends and developments in the asymmetric synthesis of profens

作     者：Qiuyue Wang Yuchen Qi Xuefeng Gao Lili Gong Ruiying Wan Weihua Lei Zhenguo Wang Jianyou Mao Haixing Guan Wei Li Patrick J.Walsh 

作者机构：College of PharmacyShandong University of Traditional Chinese MedicineJinan 250355China Experimental CenterShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic ResearchShandong University of Traditional Chinese MedicineJinan 250355China Department of Emergency MedicinePeople's Hospital of Huimin CountyBinzhou 251700China Technical Institute of FluorochemistryInstitute of Advanced SynthesisSchool of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China Roy and Diana Vagelos LaboratoriesDepartment of ChemistryUniversity of PennsylvaniaPhiladelphia 19104-6323United States 

出 版 物：《绿色合成与催化(英文)》 (Green Synthesis and Catalysis)

年 卷 期：2023年第4卷第2期

页      面：89-103页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 081705[工学-工业催化] 0817[工学-化学工程与技术] 08[工学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：the National Key Research and Development Program of China(No.SQ2017YFC170600) Key R&D plan(major innovation project)project of Shandong Province(No.2021CXGC010510) Shandong University of Traditional Chinese Medicine(Nos.2022043 and 2022050) PJW thanks the US National Science Foundation(No.CHE-2154593) 

主　　题：NSAIDs Asymmetric synthesis Transition metal catalysis Organocatalysis 

摘      要：The profens belong to a class of nonsteroidal anti-inflammatory drugs(NSAIDs),which exert significant antiinflammatory,analgesic,antipyretic and other pharmacological effects.A considerable number of catalytic asymmetric strategies for the synthesis of enantioenriched profens have been *** are outlined recent trends and developments of promising catalytic enantioselective systems for the generation of profens and their *** to the reaction type,we divided these transformations into three categories:Transition metal-catalyzed asymmetric hydrogenations,transition metal-catalyzed asymmetric cross-couplings and organocatalytic asymmetric *** of generic reaction mechanisms are ***,this tutorial review will motivate further interest in the catalytic asymmetric synthesis of highly enantioenriched profens.