Pd-Catalyzed Asymmetric Allylic C—H Functionalization

作     者：Pu-Sheng Wang Liu-Zhu Gong Pu-Sheng Wang;Liu-Zhu Gong

作者机构：Department of ChemistryUniversity of Science and Technology of ChinaHefeiAnhui 230026China Center for Excellence in Molecular Synthesis of CASUniversity of Science and Technology of ChinaHefeiAnhui 230026China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第15期

页      面：1841-1848页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Key R&D Program of China(2021YFA1500100) Youth Innovation Promotion Association CAS(2020448) NSFC(22171254 and 22188101) Anhui Provincial Natural Science Foundation(2108085MB58) USTC Research Funds of the DoubleFirst-Class Initiative(YD2060002024) Start-up Research Fund from University of Science and Technology of China(KY2060000216) 

主　　题：C-H activation Asymmetric catalysis Allylation Palladium Allylic compounds Regioselectivity Alkenes 

摘      要：Comprehensive Summary Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral,densely functionalized molecules from easily accessible alkenes,enabling the increase of the step-or atom-economy by minimizing functional group manipulations for preparing allylating *** to the inadequacy of stereoselection strategies,the asymmetric allylic C—H functionalization is still in the early *** this essay,we will describe our journey to identification of asymmetric catalytic systems,mechanism of allylic C—H activation,control of stereo-and regioselectivity,and applications in asymmetric synthesis.