Effect of levetiracetam and valproate on late‑onset post‑traumatic seizures

作     者：Yanli Wang Yiqi Wang Huifang Wang Xiaoping Du Jie Miao James X.Tao Meizhen Sun Yanli Wang;Yiqi Wang;Huifang Wang;Xiaoping Du;Jie Miao;James X. Tao;Meizhen Sun

作者机构：Department of RehabilitationShanxi Traditional Chinese Medical HospitalTaiyuan 030012China Department of NeurologyThe First Hospital of Shanxi Medical UniversityTaiyuan 030012China Department of NeurologyUniversity of ChicagoChicagoIL 60601USA 

出 版 物：《Acta Epileptologica》 (癫痫学报（英文）)

年 卷 期：2023年第6卷第2期

页      面：86-89页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funded by the Scientific Research Fund of China Association Against Epilepsy(No 2012002) 

主　　题：Levetiracetam Valproate Post-traumatic seizure 

摘      要：Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury(TBI).Methods A total of 95 patients with TBI were recruited from 2017 to *** were randomized into three groups:levetiracetam(LEV)group(n=30)receiving LEV treatment(500 mg,bid,po);valproate group(n=32)receiving sodium valproate(500 mg/d,once daily,po);and control group(n=33)receiving no anti-seizure *** and valproate were given to corresponding groups within seven days after TBI,and the administration lasted for one *** incidence of epilepsy and adverse events were evaluated at 7 days and 12 months *** The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV,valproate,and control groups were 3.33%,12.50%and 15.63%,*** cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups(P0.05).Conclusions LEV can reduce the cumulative incidence of late post-traumatic seizures,whereas valproate can not.