Primary dedifferentiated chondrosarcoma of the lung with a 4-year history of breast cancer:A case report

作     者：Huan Wen Feng-Jie Gong Jian-Min Xi 

作者机构：Department of PathologyHunan Provincial Hospital of Integrated Traditional Chinese and Western MedicineChangsha 410006Hunan ProvinceChina Department of RadiologyHunan Provincial Hospital of Integrated Traditional Chinese and Western MedicineChangsha 410006Hunan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第13期

页      面：3022-3028页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Dedifferentiated chondrosarcoma Lung Chemotherapy Radiotherapy Breast cancer Case report 

摘      要：BACKGROUND Primary dedifferentiated chondrosarcoma(DDCS)of the lung is extremely rare and has a poor prognosis,especially in patients with a history of carcinomas and related ***,we report a case of primary DDCS of the lung in a patient with a 4-year history of breast cancer and related *** SUMMARY A 49-year-old woman was admitted to our hospital with complaints of headache,dizziness,slurred speech,and dyskinesia in May *** tomography(CT)examinations showed multiple nodules in the brain,vertebral body,and both lungs with multiple enlarged lymph nodes in the right hilum and mediastinum,which were considered metastases of breast *** obvious mass was discovered in the right *** several months of related administration,the patient s headache disappeared,and her condition ***,new problems of asthma,dyspnea,cough,and restricted activity appeared in late November *** the CT scan indicated that the lesions in the brain,lung,and vertebral body had shrunk or disappeared,a soft tissue density lesion appeared in her right hilum and blocked the bronchial *** relieve her dyspnea,part of the mass was resected,and a stent was placed via fiberoptic *** a complete pathological examination of the tumor,it was confirmed to be a primary DDCS of the *** patient then received two rounds of systemic chemotherapy with a regimen of cisplatin+ifosfamide+doxorubicin hydrochloride liposome,palliative radiotherapy for the tumor in her right lung,and four cycles of systemic chemotherapy and targeted therapy with a regimen of temozolomide combined with bevacizumab *** was in stable condition after the completion of the systemic chemotherapy and targeted therapy but underwent rapid progression after lung *** CT examinations showed multiple nodules in the brain and in both lungs,and the tumor in the right hilum was increased in *** This case revealed a rare primar