A revision of the InfiniumPurify R package for genome-wide correction of tumor purity in Infinium DNA methylation array data

作     者：Phuc H.Hoang Phuc H.Hoang

作者机构：Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaMD 20892USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：698-700页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Intramural Research Program Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health USA 

主　　题：alterations purity correction 

摘      要：Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis *** many studies have highlighted the confounding effects of tumor purity in DNAm analyses,1,2,3 various tools have also been developed to tackle the issue.2,3,4 Among them,InfiniumPurify R package is a popular and widely cited tool,2,3,5 consisting of a set of statistical methods to estimate and account for tumor purity in cancer DNAm analyses.