Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

作     者：YI DONG LIANBO ZHANG XIN GUAN TAO LIU LIMIN ZHOU 

作者机构：Department of Second Breast SurgeryJilin Cancer HospitalJilin130012China Department of Medical Insurance Guarantee OfficeJilin Cancer HospitalJilin130012China Department of Breast SurgeryThe First Hospital of Jilin UniversityJilin130061China 

出 版 物：《Oncology Research》 (肿瘤学研究（英文）)

年 卷 期：2021年第29卷第4期

页      面：291-303页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Long noncoding RNA ceRNA Therapeutic intervention microRNA 

摘      要：Increasing numbers of long noncoding RNAs(lncRNAs)are implicated in breast cancer ***,the contribution of LINC02568 toward breast cancer progression remains unclear and requires further ***,we evaluated LINC02568 expression in breast cancer and clarified its effect on disease *** also investigated the mechanisms underlying the pro-oncogenic role of ***,LINC02568 was upregulated in breast cancer samples,with a notable association with worse overall ***,depleted LINC02568 suppressed cell proliferation,colony formation,and metastasis,whereas LINC02568 overexpression exerted the opposite *** mechanistic investigations suggested that LINC02568 was physically bound to and sequestered microRNA-874-3p(miR-874-3p).Furthermore,miR-874-3p mediated suppressive effects in breast cancer cells by targeting cyclin E1(CCNE1).LINC02568 positively controlled CCNE1 expression by sequestering *** experiments revealed that increased miR-874-3p or decreased CCNE1 expression recovered cell growth and motility functions induced by LINC02568 in breast cancer *** conclusion,the tumor-promoting functions of LINC02568 in breast cancer cells were enhanced by sequestering miR-874-3p and consequently over-expressing *** data may facilitate the identification of novel therapeutic targets in clinical settings.