Palladium-Catalyzed Skeletal Reorganization of Cyclobutanones Invoving Successive C—C Bond/C—H Bond Cleavage
作者机构：State Key Laboratory and Institute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin300071 China
出 版 物：《中国化学:英文版》 (Chinese Journal of Chemistry)
年 卷 期：2023年第41卷第14期
页 面：1679-1683页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the National Natural Science Foundation of China(22071114,22022103,and 21871146) the Haihe Laboratory of Sustainable Chemical Transformations,the National Key Research and Development Program of China(2019YFA0210500 and 2020YFA0711504) "Frontiers Science Center for New Organic Matter,"Nankai University(63181206)for their financial support the National Natural Science Foundation of China(52103221 and 52172048) the Shandong Provincial Natural Science Foundation(ZR2021QB179 and ZR2021ZD06) the National Key Research and Development Program of China(2022YFB4200400) funded by M0ST and the Fundamental Research Funds of Shandong University Yingguo Yang thanks the National Natural Science Foundation of China(12175298)
主 题：Cyclobutanones C-C activation C-H activation Palladium catalysis Ring expansion
摘 要：The utilization of cyclobutanones as the synthon in transition metal catalysis has been made great *** C(carbonyl)−C bond of cyclobutanones can be cleaved through strain *** those advancements,the main catalysts in literature are Rh catalysts or Ni catalysts and the reaction with C—H bond is still ***,we realized the first palladium-catalyzed skeletal reorganization of cyclobutanones involving successive cleavage of C(carbonyl)−C bonds and C—H bond cleavage,which constitutes an rapid access to diverse *** contrast to the previous Rh-catalytic system,the Pd-catalytic system herein involves different mechanism and features several advantages:1)no need of directing group to facilitate the C(carbonyl)−C bond cleavage;2)much milder reaction condition and 3)simplified work-up.
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