Era of the 4D animal model

作     者：Lihong Zhang Jindan Guo Jiangning Liu Lihong Zhang;Jindan Guo;Jiangning Liu

作者机构：NHC Key Laboratory of Human Disease Comparative MedicineBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2023年第6卷第2期

页      面：178-182页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：CAMS Innovation Fund for Medical Sciences(CIFMS)grant(2022-I2M-1-020 and 2021-1-I2M-035) the National Natural Science Foundation of China(NSFC)(92169210)。 

主　　题：animal model database digitally display human diseases spatiotemporal landscapes 

摘      要：Revealing the entire dynamics of pathogenesis is critical for understanding,preventing and treating human disease but is limited by systematic clinical sampling.This drawback can be overcome with animal model studies.Recent advances in phenotyping,omics and bioinformatics technologies promote the development of the 4D animal model to simulate and digitally display the spatiotemporal landscapes of phenotypes and molecular dynamics in human diseases and reveal novel targets for diagnosis and therapy.In this commentary,the origin,supporting technologies,content,function and application,and advantages of 4D animal models over clinical studies and traditional animal models,as well as their limitations,are presented.