The global epidemiology of upper and lower gastrointestinal bleeding in general population:A systematic review

作     者：Şiir Su Saydam Megan Molnar Pareen Vora 

作者机构：Integrated Evidence GenerationBayer AGBerlin 13353Germany 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第4期

页      面：723-739页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by Bayer AG 

主　　题：Gastrointestinal bleeding Gastrointestinal haemorrhage Epidemiology Incidence Mortality Case-fatality 

摘      要：BACKGROUND Gastrointestinal bleeding(GIB)is a common and potentially life-threatening clinical *** date,the literature on the long-term global epidemiology of GIB has not been systematically *** To systematically review the published literature on the worldwide epidemiology of upper and lower *** EMBASE®and MEDLINE were queried from 01 January 1965 to September 17,2019 to identify population-based studies reporting incidence,mortality,or casefatality rates of upper GIB(UGIB)or lower GIB(LGIB)in the general adult population,*** outcome data were extracted and summarized(including data on rebleeding following initial occurrence of GIB when available).All included studies were assessed for risk of bias based upon reporting *** Of 4203 retrieved database hits,41 studies were included,comprising a total of around 4.1 million patients with GIB worldwide from 1980–***-three studies reported rates for UGIB,four for LGIB,and four presented data on *** rates ranged from 15.0 to 172.0/100000 person-years for UGIB,and from 20.5 to 87.0/100000 person-years for *** studies reported on temporal trends,generally showing an overall decline in UGIB incidence over time,although a slight increase between 2003 and 2005 followed by a decline was shown in 5/13 ***-related mortality data were available from six studies for UGIB,with rates ranging from 0.9 to 9.8/100000 person-years,and from three studies for LGIB,with rates ranging from 0.8 to 3.5/100000 *** rate ranged from 0.7%to 4.8%for UGIB and 0.5%to 8.0%for *** of rebleeding ranged from 7.3%to 32.5%for UGIB and from 6.7%to 13.5%for *** main areas of potential bias were the differences in the operational GIB definition used and inadequate information on how missing data were *** Wide variation was seen in estimates of GIB epidemiology,likely due to high heterogeneity between studies however,UGIB sho