The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

作     者：Jie Chen Xiaohong Wei Qian Zhang Yuzhuo Wu Guiyang Xia Huan Xia Lingyan Wang Hongcai Shang Sheng Lin Jie Chen;Xiaohong Wei;Qian Zhang;Yuzhuo Wu;Guiyang Xia;Huan Xia;Lingyan Wang;Hongcai Shang;Sheng Lin

作者机构：Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingDongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第5期

页      面：1919-1955页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Key Research&Development Program of China(Grant Nos.2017YFC1700400,2017YFC1700403) National Natural Science Foundation of China(NNSFC Grant Nos.82073978,81725024,and 82104441) Beijing Natural Science Foundation(Grant No.JQ18026,China) 

主　　题：Natural ingredients Chronic heart failure Cardiac remodeling Chinese medicinal herbs Traditional Chinese medicine formula Multiple targets Constituent compatibility Synergistic effects 

摘      要：Chronic heart failure(CHF)is a severe public health problem with increasing morbidity and mortality,any treatment targeting a single session is insufficient to tackle *** is characterized by reduced cardiac output resulting from neurohumoral dysregulation and cardiac remodeling,which might be related to oxidative stress,inflammation,endoplasmic reticulum stress,apoptosis,autophagy,mitochondrial function,and *** molecular mechanisms interact with each other through ***,Chinese medicinal herbs have been widely applied in the treatment of CHF,and therapeutic effects of Chinese medicinal herbs and their ingredients have been scientifically confirmed over the past *** Chinese medicine(TCM)with multiple components can confront the different pathogenesis of CHF through multiple *** review analyzes commonly used TCM patent drugs and TCM decoctions that are applicable to different stages of CHF based on clinical *** bioactive ingredients in Chinese medicinal herbs have been found to treat CHF via multiple molecular *** review comprehensively covers the key works on the effects and underlying mechanisms of TCM,herbal ingredients and synergistic effects of constituent compatibility in treating CHF,providing additional ideas to address this threat.