The role of glutamine metabolism in castration-resistant prostate cancer
作者机构：Department of GeriatricsThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230002China Department of Urologic OncologyThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Department of NursingThe First Affiliated Hospital of Anhui Medical UniversityHefei 230001China Department of UrologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230001China Institute of UrologyAnhui Medical UniversityHefei 230001China Anhui Province Key Laboratory of Genitourinary DiseasesAnhui Medical UniversityHefei 230001China Department of PathologyDuke University School of MedicineDurhamNC 27710USA Duke Cancer InstituteDuke University School of MedicineDurhamNC 27710USA
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2023年第25卷第2期
页 面：192-197页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was partially supported by the National Natural Science Foundation of China(No.81902611,No.82272886,and No.82200484) the Natural Science Foundation of Anhui Education Department(No.2022AH030118).
主 题：castration resistance glutamine metabolism prostate cancer tumor metabolism
摘 要：Reprogramming of metabolism is a hallmark of tumors,which has been explored for therapeutic purposes.Prostate cancer(PCa),particularly advanced and therapy-resistant PCa,displays unique metabolic properties.Targeting metabolic vulnerabilities in PCa may benefit patients who have exhausted currently available treatment options and improve clinical outcomes.Among the many nutrients,glutamine has been shown to play a central role in the metabolic reprogramming of advanced PCa.In addition to amino acid metabolism,glutamine is also widely involved in the synthesis of other macromolecules and biomasses.Targeting glutamine metabolic network by maximally inhibiting glutamine utilization in tumor cells may significantly add to treatment options for many patients.This review summarizes the metabolic landscape of PCa,with a particular focus on recent studies of how glutamine metabolism alterations affect therapeutic resistance and disease progression of PCa,and suggests novel therapeutic strategies.
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