Immunological Markers for Central Nervous System Glia

作     者：Hao Huang Wanjun He Tao Tang Mengsheng Qiu 

作者机构：Zhejiang Key Laboratory of Organ Development and RegenerationInstitute of Life SciencesCollege of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China Department of AnatomyCell Biology and Physiology Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN 46202USA 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第3期

页      面：379-392页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(31900703 and 32170969) a Ministry of Science and Technology China Brain Initiative Grant(2022ZD0204701). 

主　　题：Glial cells Oligodendrocytes Astrocytes Microglia Markers 

摘      要：Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and microglia.They contribute more than half of the total cells of the CNS,and are essential for neural development and functioning.Studies on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular markers.However,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible confusion.Here,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression.