Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis
作者机构：Department of NeurologyRen Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2023年第39卷第3期
页 面：466-478页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学]
主 题：Multiple sclerosis·Inflammation Neurodegeneration Glial cells
摘 要：Multiple sclerosis(MS)is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration.Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described.However,with the innovation of technology in glial cell research,we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS.In this review,we focus on the role of glial cells,including microglia,astrocytes,and oligodendrocytes,in the pathogenesis of MS.We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss.
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