单基因遗传性高血压:一类可“治愈”的高血压
Monogenic hypertension-a type of “curable”hypertension作者机构：Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Center for Applied GenomicsChildren’s Hospital of Philadelphia and the Division of Human GeneticsDepartment of PediatricsPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia 19104USA Department of Non-Communicable Disease ManagementBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Emergency and Critical Care CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China
出 版 物：《Science Bulletin》 (科学通报（英文版）)
年 卷 期：2023年第68卷第7期
页 面：657-660页
核心收录：
基 金：This work was supported by the National Key Research and Development Program of China(2016YFC1300100) the CAMS Innovation Fund for Medical Sciences(2022-I2M-C&T-A-010 and 2022-I2M-C&T-A-011).
主 题：elevated hypertensive mortality
摘 要：Hypertension is a global problem that affects more than 1 billion people worldwide with the increased prevalence year by year[1,2].It contributes to major impacts on health including morbidity and all-cause mortality,as well as consumption of substantial health care expenses.Understanding the complex pathophysiology and risk factors involved in the development of elevated blood pressure can help treat the disease to better prevent life-threatening conditions and alleviate the socio-economic burden.The hereditary nature of hypertension relies on that up to 30%of blood pressure variation is due to genetics and an individual’s genetic predisposition to hypertensive disease ranges from 15%to 35%[3].
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