Rational design of hydrogels for immunomodulation

作     者：Wenhuan Bu Yuanhao Wu Amir M.Ghaemmaghami Hongchen Sun Alvaro Mata 

作者机构：Liaoning Provincial Key Laboratory of Oral DiseasesSchool of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Dental MaterialsSchool of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Center LaboratorySchool of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Biodiscovery InstituteUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of ImmunologySchool of Life SciencesUniversity of NottinghamUniversity ParkNottingham NG72RDUK Terasaki Institute for Biomedical Innovation1018 Westwood BlvdLos AngelesCA 90024USA Department of Chemical and Environmental EngineeringUniversity of NottinghamUniversity ParkNottingham NG72RDUK 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：979-1000页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the ERC Proof-of-Concept Grant(MINGRAFT),the AO Foundation Grant(AOCMF-17-19M) the Medical Research Council(UK Regenerative Medicine Platform Acellular/Smart Materials-3D Architecture,MR/R015651/1) the National Natural Science Foundation of China(81870741,82001023),China Postdoctoral Science Foundation(2019M661177) Natural Science Foundation of Liaoning Province(2020-MS-154) China Scholarship Council(50). 

主　　题：hydrogels immunomodulation physical properties chemical properties 

摘      要：The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development,repair and regeneration.Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes,short half-life and lack of targeting ability.Encapsulating or binding these biologics within biomaterials is an effective way to address these problems.Hydrogels are promising immunomodulatory materials because of their prominent biocompatibility,tuneability and versatility.However,to take advantage of these opportunities and optimize material performance,it is important to more specifically elucidate,and leverage on,how hydrogels affect and control the immune response.Here,we summarize how key physical and chemical properties of hydrogels affect the immune response.We first provide an overview of underlying steps of the host immune response upon exposure to biomaterials.Then,we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through(i)physical properties including dimensionality,stiffness,porosity and topography;(ii)chemical properties including wettability,electric property and molecular presentation;and(iii)the delivery of bioactive molecules via chemical or physical cues.Thus,this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response.