A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106

作     者：Yaqin FAN Chunjiao JIANG Peihai LI Cong WANG Hao CHEN Yaqin FAN;Chunjiao JIANG;Peihai LI;Cong WANG;Hao CHEN

作者机构：MNR Key Laboratory of Marine Eco-Environmental Science and TechnologyFirst Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Shandong Provincial Key Laboratory of Applied MycologySchool of Life SciencesQingdao Agricultural UniversityQingdao 266109China Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong ProvinceShandong Provincial Engineering Laboratory for Biological Testing TechnologyKey Laboratory for Biosensor of Shandong ProvinceBiology InstituteQilu University of Technology(Shandong Academy of Sciences)Jinan 250103China Key Laboratory of Chemistry and Engineering of Forest ProducerState Ethnic Affairs CommissionGuangxi Key Laboratory of Chemistry and Engineering of Forest ProductsGuangxi Collaborative Innovation Center for Chemistry and Engineering of Forest ProductsSchool of Chemistry and Chemical EngineeringGuangxi Minzu UniversityNanning 53006China 

出 版 物：《Journal of Oceanology and Limnology》 (海洋湖沼学报（英文）)

年 卷 期：2023年第41卷第3期

页      面：1145-1151页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(No42006096) the Shandong Provincial Natural Science Foundation(No ZR2020QD098) the China Postdoctoral Science Foundation(No2020M682266) 

主　　题：marine natural products marine-Keyword:marine nabta globosum pro-angjogo nesis activity 

摘      要：A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture extract of Chaetomium globosum YP-106,a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap *** structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic,mass spectrometry(MS)data analysis and comparison with the reported *** absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism(ECD).All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish *** 1,2,and 5significantly promoted the angiogenesis in a dose-dependent manner and thus,these compounds might be used as promising molecules for the treatment of cardiovascular disease.