Eff ect of post-rewarming fever after targeted temperature management in cardiac arrest patients: a systematic review and meta-analysis

作     者：Guang-qi Guo Yan-nan Ma Shuang Xu Hong-rong Zhang Peng Sun Guang-qi Guo;Yan-nan Ma;Shuang Xu;Hong-rong Zhang;Peng Sun

作者机构：Department of Emergency MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2023年第14卷第3期

页      面：217-223页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82072137 81571866) 

主　　题：Cardiac arrest Target temperature management Post-rewarming fever Rebound hyperthermia 

摘      要：BACKGROUND:Targeted temperature management(TTM),as a therapeutic temperature control strategy for cardiac arrest(CA),is recommended by ***,the relationship between postrewarming fever(PRF)and the prognosis of CA patients is ***,we aim to summarize the studies regarding the infl uence of PRF on patients with ***:EMBASE,PubMed,and Cochrane Central databases were searched from inception to March 13,*** clinical trials(RCTs)and cohort studies on PRF in CA patients were *** to the heterogeneity,the meta-analysis was performed using a random eff ects model or fi xed eff ects model to calculate the pooled odds ratios(ORs)and corresponding 95%confi dence intervals(CIs).The outcome data were unfavorable neurological outcome and ***:The meta-analysis included 11 observational studies involving 3,246 *** results of the meta-analysis show that PRF(body temperature38.0℃)has no eff ect on the neurological outcome of CA patients(OR 0.71,95%CI 0.43–1.17,I282%)and has a signifi cant relationship with lower mortality(OR 0.63;95%CI 0.49–0.80,I239%).However,PRF with a stricter defi nition(body temperature38.5℃)was associated with worse neurological outcome(OR 1.44,95%CI 1.08–1.92,I245%)and higher mortality(OR 1.71,95%CI 1.25–2.35,I247%).CONCLUSION:This study suggests that PRF38.0℃ may not affect the neurological outcome and have a lower mortality in CA patients who completed ***,PRF38.5℃ is a potential prognostic factor for worse outcomes in CA patients.