In vivo study on heparin/poly-L-lysine-copper coating for surface functionalization of ureteral stent
作者机构：Innovation Center for Advanced MaterialsInstitute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Department of UrologyGeneral Hospital of Northern Theater CommandShenyang 110840China Department of UrologyThe First Affiliated Hospital of China Medical UniversityShenyang 110001China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2022年第9卷第1期
页 面：955-962页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：Liaoning Science and Technology Program(grant No.2020JH2/10300159).
主 题：ureteral stent heparin/PLL-Cu nanoparticles in vivo implantation bacterial adhesion encrustation
摘 要：Polyurethane(PU)ureteral stents are used in clinics to maintain the ureteral patency.Due to biofilm formation and encrustation complications,long-term clinical usage has been limited.It is therefore necessary to develop an effective response to this unmet medical need.A heparin/poly-L-lysine/copper(NPs)coating was developed in our previous work that showed the effect of preventing infection and encrustation in vitro.In this work,a further study was conducted by grafting NPs on clinical ureteral stents that then were implanted into the infectious bladders of Wistar rats to investigate the effects of nanoparticles on bacterial growth and crystal deposition in vivo.It was found that decreased numbers of adherent microbes,urease amount splitting by bacteria,and deposited crystals were observed on the NPs stents with significant differences in comparison with PU stents.Besides,histological analysis showed that the NPs stents decreased the host tissue inflammation in close relation to the decrease biofilm formation and encrustation after 28 days of implantation.
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