Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders

作     者：Di Yao Ruoying Zhang Minjie Xie Fengfei Ding Minghuan Wang Wei Wang 

作者机构：Department of NeurologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of PharmacologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Key Laboratory of Neurological Diseases of the Chinese Ministry of EducationSchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第3期

页      面：503-518页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：supported by the Ministry of Science and Technology China Brain Initiative Grant(2022ZD0204704) the National Natural Science Foundation of China(81974180) the Young Excellent Medical Scholarship of Hubei Province(2020LJRCO11). 

主　　题：Glial-vascular unit Perivascular space Blood-brain barrier Glymphatic system Ischemic stroke Spinal cord injury Alzheimer's disease Major depression disorder 

摘      要：The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordinated reactions to diverse neurological insults from a“glio-centricview.GVU is a multicellular structure composed of glial cells,perivascular cells,and perivascular space.Each component is closely linked,collectively forming the GVU.The central roles of glial and perivascular cells and their multi-level interconnections in the GVU under normal conditions and in central nervous system(CNS)disorders have not been elucidated in detail.Here,we comprehensively review the intensive interactions between glial cells and perivascular cells in the niche of perivascular space,which take part in the modulation of cerebral blood flow and angiogenesis,formation of the blood-brain barrier,and clearance of neurotoxic wastes.Next,we discuss dysfunctions of the GVU in various neurological diseases,including ischemic stroke,spinal cord injury,Alzheimer’s disease,and major depression disorder.In addition,we highlight the possible therapies targeting the GVU,which may have potential clinical applications.