Clinical implication of platelet to lymphocyte ratio in early onset preeclampsia:A single-center experience

作     者：Wisam Akram Zina Abdullah Hussein Mazin Hameed Humadi Wassan Nori 

作者机构：Obstetrics and GynecologyMustansiriyah UniversityBaghdad 10052Iraq Department of InspectionMinistry of HealthBaghdad 10052Iraq 

出 版 物：《World Journal of Obstetrics and Gynecology》 (世界妇产科杂志)

年 卷 期：2023年第12卷第3期

页      面：17-27页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：the ethical committee of Mustansiriyah University(No.160) 

主　　题：Preeclampsia Early onset Maternal complication Adverse perinatal outcome Apgar score 

摘      要：BACKGROUND Preeclampsia(PE)is a pregnancy syndrome of undetermined etiology;inflammation was one of the proposed theories for its *** To examine the platelet to lymphocyte ratio(PLR),an inflammatory biomarker,as a marker to predict poor maternal-neonatal outcomes in early-onset PE(EoPE).METHODS A cross-sectional study enrolled 60 pregnant women with EoPE(at 32-30 wk of gestation)at a university *** criteria and hematological indices were collected,including platelet counts and indices(mean platelet volume and platelet distribution width),PLR,and the Doppler study,which calculated estimated fetal weight(EFW),amniotic fluid index(AFI),resistance index(RI),and pulsatility index(PI).Participants were followed until delivery,where maternal outcomes were recorded,including;delivery mode and reason for cesarean section,and neonatal outcomes,including fetal growth restriction(FGR),meconium-stained liquid,the 5-min Apgar score,and admission to the intensive care *** There was a trend of insignificant increases in cesarean ***-one-point two percent(37/60)fetuses were admitted to the neonatal care unit;70.0%of admitted fetuses were meconium-stained liquor,and 56.7%of them had *** was positively correlated with AFI and EFW as r=0.98,0.97,P0.001;PLR showed negative correlations with PI and RI as r=-0.99,-0.98,P*** Apgar score and the number of days admitted to the intensive care unit had a positive and negative correlation(0.69,-0.98),P0.0001,*** operating characteristic calculated a PLR cutoff value(7.49)that distinguished FGR at 100%sensitivity and 80%*** Strong,meaningful relationships between PLR and FGR parameters and a poor neonatal outcome with a significant P value make it a recommendable biomarker for screening EoPE-related *** studies are suggested to see the impact on maternal-neonatal health.