Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

作     者：Qiong Huang Yuqi Yang Tianjiao Zhao Qiaohui Chen Min Liu Shuting Ji Yan Zhu Yunrong Yang Jinping Zhang Haixin Zhao Yayun Nan Kelong Ai 

作者机构：Department of PharmacyXiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha410008China Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China Hunan Provincial Key Laboratory of Cardiovascular ResearchXiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China Geriatric Medical CenterPeople’s Hospital of Ningxia Hui Autonomous RegionYinchuan750002China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第21卷第3期

页      面：381-393页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：National Natural Science Foundation of China(No.81974508,21974134) Hunan Science Fund for Distinguished Young Scholar of China(No.2021JJ10067) Innovation-Driven Project of Central South University(No.202045005) Hunan Provincial Natural Science Foundation of China(No.2021JJ31066) Key Research Project of Ningxia Hui Autonomous Region in 2021 of China(Major Project)(No.2021BEG01001) Key Program of Ningxia Hui Autonomous Region Natural Science Foundation of China(No.2022JJ21059) 

主　　题：ROS-scavenging Anti-inflammatory Acute kidney injury Passively-targeted mitochondrial Tungsten-Based Nanodots 

摘      要：Acute kidney injury(AKI)can lead to loss of kidney function and a substantial increase in *** burst of reactive oxygen species(ROS)plays a key role in the pathological progression of ***-targeted antioxidant therapy is very promising because mitochondria are the main source of ROS in *** nanodrugs with actively targeted mitochondria have achieved encouraging success in many oxidative stress-induced ***,most strategies to actively target mitochondria make the size of nanodrugs too large to pass through the glomerular system to reach the renal tubules,the main damage site of ***,an ultra-small Tungsten-based nanodots(TWNDs)with strong ROS scavenging can be very effective for treatment of *** can reach the tubular site after crossing the glomerular barrier,and enter the mitochondria of the renal tubule without resorting to complex active targeting *** our knowledge,this is the first time that ultra-small negatively charged nanodots can be used to passively target mitochondrial therapy for *** in-depth study of the therapeutic mechanism,such passive mitochondria-targeted TWNDs are highly effective in protecting mitochondria by reducing mitochondrial ROS and increasing *** addition,TWNDs can also reduce the infiltration of inflammatory *** work provides a new way to passively target mitochondria for AKI,and give inspiration for the treatment of many major diseases closely related to mitochondria,such as myocardial infarction and cerebral infarction.