Bone without borders-Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

作     者：Furqan A.Shah Martina Jolic Chiara Micheletti Omar Omar Birgitta Norlindh Lena Emanuelsson Håkan Engqvist Thomas Engstrand Anders Palmquist Peter Thomsen 

作者机构：Department of BiomaterialsSahlgrenska AcademyUniversity of GothenburgGothenburgSweden Department of Materials Science and EngineeringMcMaster UniversityHamiltonOntarioCanada Department of Engineering SciencesApplied Materials Science SectionUppsala UniversityUppsalaSweden Department of Reconstructive Plastic SurgeryKarolinska University HospitalStockholmSweden 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第19卷第1期

页      面：103-114页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：Eivind och Elsa K:son Sylvans Stiftelse Kungliga Vetenskaps- och Vitterhets-Samh? Swedish government, (ALFGBG-725641) Västra Götalandsregionen Kungl. Vetenskaps- och Vitterhets-Samhället i Göteborg, KVVS Stiftelsen för Strategisk Forskning, SSF, (RMA15-0110) Forskningsrådet för Arbetsliv och Socialvetenskap, FAS Adlerbertska Stiftelserna Stiftelsen Handlanden Hjalmar Svenssons IngaBritt och Arne Lundbergs Forskningsstiftelse Vetenskapsrådet, VR, (2017-04728, 2018-02891, 2020-04715) Göteborgs Universitet Uppsala Universitet 

主　　题：Bone Calcium phosphate Monetite Calcium pyrophosphate Electron microscopy Raman spectroscopy 

摘      要：Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive biomaterials.As proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium pyrophosphate)guides osteogenesis beyond the physiological envelope.In a sheep model,hollow dome-shaped constructs were placed directly over the occipital bone.At 12 months,large amounts of bone(~75%)occupy the hollow space with strong evidence of ongoing remodelling.Features of both compact bone(osteonal/osteon-like arrangements)and spongy bone(trabeculae separated by marrow cavities)reveal insights into function/need-driven microstructural adaptation.Pores within the CaP also contain both woven bone and vascularised lamellar bone.Osteoclasts actively contribute to CaP degradation/removal.Of the constituent phases,only calcium pyrophosphate persists within osseous(cutting cones)and non-osseous(macrophages)sites.From a translational perspective,this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge.