Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
作者机构：Department of Emergency MedicineState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Disaster Medicine CenterWest China HospitalSichuan UniversityChengduSichuan610041China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第6期
页 面：2577-2598页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：supported by the National Key Research and Development Program of China(Grant no.2022YFC2303702) the National Natural Science Foundation of China(Grant no.81971925) the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant no.ZYYC20008)
主 题：vaccines prevention elements
摘 要：The ongoing global pandemic of coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),has caused devastating impacts on the public health and the global *** viral antigenic evolution has led to the continual generation of new *** special note is the recently expanding Omicron subvariants that are capable of immune evasion from most of the existing neutralizing antibodies(nAbs).This has posed new challenges for the prevention and treatment of ***,exploring broad-spectrum antiviral agents to combat the emerging variants is *** sharp contrast to the massive accumulation of mutations within the SARS-CoV-2 receptor-binding domain(RBD),the S2 fusion subunit has remained highly conserved among ***,S2-based therapeutics may provide effective cross-protection against new SARS-CoV-2 ***,we summarize the most recently developed broad-spectrum fusion inhibitors(e.g.,nAbs,peptides,proteins,and small-molecule compounds)and candidate vaccines targeting the conserved elements in SARS-CoV-2 S2 *** main focus includes all the targetable S2 elements,namely,the fusion peptide,stem helix,and heptad repeats 1 and 2(HR1-HR2)***,we provide a detailed summary of the characteristics and action-mechanisms for each class of cross-reactive fusion inhibitors,which should guide and promote future design of S2-based inhibitors and vaccines against new coronaviruses.
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