Supramolecular hybrid hydrogels as rapidly on-demand dissoluble,self-healing,and biocompatible burn dressings

作     者：A.Aslihan Gokaltun Letao Fan Luca Mazzaferro Delaney Byrne Martin L.Yarmush Tianhong Dai Ayse Asatekin O.Berk Usta 

作者机构：Center for Engineering in Medicine and SurgeryMassachusetts General HospitalHarvard Medical School55 Fruit St.BostonMA02114USA Shriners Hospitals for Children51 Blossom St.BostonMA02114USA Department of Chemical and Biological EngineeringTufts University4 Colby St.MedfordMA02474USA Department of Chemical EngineeringHacettepe University06532BeytepeAnkaraTurkey Department of Biomedical EngineeringRutgers University599 Taylor Rd.PiscatawayNJ08854USA Wellman Center for PhotomedicineMassachusetts General HospitalDepartment of DermatologyHarvard Medical School50 Blossom StreetBostonMA02114USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第25卷第7期

页      面：415-429页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This research was supported partially by grants from the National Institutes of Health(NIH 5R21GM136002,NIH 1R21GM141683,and NIH 5R01HL145031) National Science Foundation(NSF Grant CHE-1904465 and EEC-1941543) a Massachusetts General Hospital(MGH)Executive Committee on Research(ECOR)Interim Support Fund,and a Shriners Hospital Research Grant(SHC 85125,and 85128) 

主　　题：Supramolecular hybrid hydrogels Cationic copolymer On-demand dissoluble Self-healable Biocompatible Burn injury 

摘      要：Despite decades of efforts,state-of-the-art synthetic burn dressings to treat partial-thickness burns are still far from *** dressings adhere to the wound and necessitate *** work describes the first“supramolecular hybrid hydrogel(SHH)burn dressing that is biocompatible,self-healable,and on-demand dissoluble for easy and trauma-free removal,prepared by a simple,fast,and scalable *** SHHs leverage the interactions of a custom-designed cationic copolymer via host-guest chemistry with cucurbit[7]uril and electrostatic interactions with clay nanosheets coated with an anionic polymer to achieve enhanced mechanical properties and fast on-demand *** SHHs show high mechanical strength(50 kPa),self-heal rapidly in~1 min,and dissolve quickly(4-6 min)using an amantadine hydrochloride(AH)solution that breaks the supramolecular interactions in the *** the SHHs nor the AH solution has any adverse effects on human dermal fibroblasts or epidermal keratinocytes in *** SHHs also do not elicit any significant cytokine response in ***,in vivo murine experiments show no immune or inflammatory cell infiltration in the subcutaneous tissue and no change in circulatory cytokines compared to sham ***,these SHHs present excellent burn dressing candidates to reduce the time of pain and time associated with dressing changes.