Bexarotene improves motor function after spinal cord injury in mice

作     者：Xingyu Wang Zhihao Shen Haojie Zhang Hao-Jie Zhang Feida Li Letian Yu Hua Chen Kailiang Zhou Hui Xu Sunren Sheng Xingyu Wang;Zhihao Shen;Haojie Zhang;Hao-Jie Zhang;Feida Li;Letian Yu;Hua Chen;Kailiang Zhou;Hui Xu;Sunren Sheng

作者机构：Department of OrthopedicsThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Zhejiang Provincial Key Laboratory of OrthopedicsWenzhouZhejiang ProvinceChina The Second Clinical Medical College of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Renji College of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第12期

页      面：2733-2742页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：grants from Zhejiang Provincial Medicine and Health Technology Project,No.2021KY214(to SS) Zhejiang Provincial Science and Technology Project of Traditional Chinese Medicine,No.2021ZB183(to HX) 

主　　题：3-methyladenine AMP-activated protein kinase autophagy bexarotene mitophagy oxidative stress pyroptosis reactive oxygen species spinal cord injury transcription factor E3 

摘      要：Spinal cord injury is a challenge in orthopedics because it causes irreversible damage to the central nervous ***,early treatment to prevent lesion expansion is crucial for the management of patients with spinal cord ***,a type of retinoid,exerts therapeutic effects on patients with cutaneous T-cell lymphoma and Parkinson s *** has been proven to promote autophagy,but it has not been used in the treatment of spinal cord *** investigate the effects of bexarotene on spinal cord injury,we established a mouse model of T11–T12 spinal cord contusion and performed daily intraperitoneal injection of bexarotene for 5 consecutive *** found that bexarotene effectively reduced the deposition of collagen and the number of pathological neurons in the injured spinal cord,increased the number of synapses of nerve cells,reduced oxidative stress,inhibited pyroptosis,promoted the recovery of motor function,and reduced *** of autophagy with 3-methyladenine reversed the effects of bexarotene on spinal cord *** enhanced the nuclear translocation of transcription factor E3,which further activated AMP-activated protein kinase-S-phase kinase-associated protein 2-coactivator-associated arginine methyltransferase 1 and AMP-activated protein kinase-mammalian target of rapamycin signaling *** injection of transcription factor E3 sh RNA or intraperitoneal injection of compound C,an AMP-activated protein kinase blocker,inhibited the effects of *** findings suggest that bexarotene regulates nuclear translocation of transcription factor E3 through the AMP-activated protein kinase-Sphase kinase-associated protein 2-coactivator-associated arginine methyltransferase 1 and AMP-activated protein kinase-mammalian target of rapamycin signal pathways,promotes autophagy,decreases reactive oxygen species level,inhibits pyroptosis,and improves motor function after spinal cord injury.