A Brief Review of Animal Models for COVID-19

作     者：MIAO Jinxin SONG Shaohe HOU Xinyue ZHANG Sen XUE Xia 苗晋鑫;宋韶鹤;侯心悦;张森;薛夏

作者机构：Academy of Chinese Medicine ScienceHenan University of Chinese MedicineZhengzhouHenan 450046 China Department of Pharmacythe First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenan 450000 China Precision Medicine Center of the Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450001 China 

出 版 物：《Chinese Medicine and Natural Products》 (中医学报（英文）)

年 卷 期：2021年第1卷第2期

页      面：37-49页

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：We thank for the funding support from the Key Scientifie Research Projects of Henan Province Colleges and Universities(21 A360021) Natural Science Foundation of Henan Province(202300410259) Postdoctoral Research Startup Project in Henan Province(202001043) Special Program of the Postdoctoral Science Foundation of China(2021 T140184) 

主　　题：animal models COVID-19 coronavirus vaccine Chinese medicine 

摘      要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes an outbreak of corona virus disease 2019(COVID-19)*** is to date one of the biggest public health threat in the *** studies on this emerging coronavirus have developed rapidly since the COVID-19 case was confirmed,there is much remains unknown about *** better understand the mechanism of cross-species transmission and search for efficient vaccines and therapeutics for COVID-19,animal models are highly required to evaluate countermeasures against emerging *** ideal animal model should respond as similar as human be-ings to SARS-CoV-2 infection and show analogical symptoms,reflecting the human beings clinical sign,viral replication,and pathology that can be applied to identify in human ***,several animal models have been developed to study SARS-CoV-2 and aim to find new vaccines,antiviral agents,and Chinese materia medica very *** aim to review the climical presentations of COVID-19 concerning pathologic features in humans and summarize the current animal models strengths and limitations of use for SARS-CoV-2.