Antidepressant-like Effects of Flavonoids from Pteridium aquilinum ***

作     者：Zimeng FENG Xiang HAN Shuangli LIU Xiaohui WANG 

作者机构：Research Center of Agricultural Environment and ResourcesJilin Academy of Agricultural SciencesChangchun 130033China National&Local Joint Engineering Research Center for Ginseng Breeding and ApplicationJilin Agricultural UniversityChangchun 130033China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2023年第14卷第1期

页      面：55-63页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Innovation Project of Jilin Academy of Agricultural Sciences(cxgc2017zy011) Major Project of Jilin Province Science and Technology Department(20170204046ny) 

主　　题：Pteridium aquilinum var.latiusculum Central nervous system LPS-induced depression Inflammation Neurotrophy 

摘      要：[Objectives]To explore the antidepressant-like effects of PAFL and its potential mechanisms.[Methods]This study used PAFL in mice under various conditions and analyzed the *** antidepressant-like effects of flavonoids from Pteridium aquilinum(PAFL)and its possible action mechanism were discussed.[Results]PAFL(5 mg/kg,i.p.)exhibited markedly antidepressant-like activities,which could be reversed by treatment with p-chlorophenylalanine(an inhibitor of 5-HT synthesis),haloperidol(a non-selective D 2 receptor antagonist)and N-methyl-D-aspartic acid(an agonist at the glutamate site).Meanwhile,PAFL also effectively increased the hippocampus 5-HT,DA,and Glu levels of mice exposed to TST and *** LPS-induced antidepressant behavioral experiment showed that PAFL(1 and 5 mg/kg,i.p.)and fluoxetine(20 mg/kg,i.p.)effectively reduced the immobility time,and increase activity time in *** pretreatment significantly reduced IL-6 and TNF-αserum levels and improve the changes of hippocampal SOD and MDA oxidative stress ***,PAFL preconditioning could up-regulate BDNF and TrκB contents in hippocampus and down-regulate IκB-αand NF-κB phosphorylation.[Conclusions]The antidepressant-like effects of PAFL might be mediated by the 5-HT,DAergic and Gluergic systems,and the mechanisms of anti-depressant effects of PAFL might be via the alterations of animal behaviors,hippocampus inflammation and neurotrophy,which might be attributed by the BDNF/TrκB/NF-κB signaling pathway.